Palladium-catalyzed couplings to 7-azaindoles with formation of C-C bonds

In recent years, compounds with the 1H-pyrrolo[2,3-b]pyridine moiety (more commonly named 7-azaindole; Mérour and Joseph, 2001) have been shown to display significant biological activities. Following these observations, the synthesis of variously substituted 7-azaindole derivatives has become a subject of major concern for medicinal chemists. As a continuation of our precedent review (AtlanChim newsletter N°3), we present herein known examples of palladium-catalyzed carbon-carbon bond formation at carbons C2, C3, C4, C5 and C6 of the 7-azaindole nucleus.

NB : Patent literature is not included in this review.