Cobalt-catalyzed preparation of quinoxalines Quinoxaline is an important heterocycle present in a plethora of compounds with a wide range of…

An efficient multicomponent Mannich reaction to prepare substituted amines An efficient three-component one-pot condensation of primary, secondary, and tertiary organozinc…

Deoxyfluorination of electron-deficient phenols with 2-chloroimidazolium dihydrogen trifluoride salt. An efficient preparation of 2-chloro-1,3-bis(2,6-diisopropylphenyl)imidazolium dihydrogen trifluoride salt A (Scheme below…

Palladium-catalyzed cyanation of aryl sulfonium salts with potassium ferrocyanide Aromatic nitriles are of significant importance in synthetic organic chemistry, as…

Palladium-catalyzed Buchwald-Hartwig amination Since the pioneering investigations of Migita et Coll. in 1983 and the simultaneous outstanding contributions of Buchwald…

1‑Substituted isoquinolines synthesis by heterocyclization of TosMIC derivatives In 2016, Vaquero and Coll. published an original preparation of various 1‑substituted…

1,8-DiazaBicyclo[5.4.0]Undec-7-ene (DBU): unexpected side reactions In 2019, A. M. Hyde and Coll. from the Department of Process Research & Development…

Multikilogram-scale Birch reduction Birch Reduction is an important reduction reaction in organic chemistry, in particular to reduce aromatic rings. [1]…

Efficient preparation of 4-Cyanooxazoles from aldehydes In medicinal chemistry, efficient methodologies to construct heterocycles on small scale from common functional…

N,N-Dimethylformamide (DMF) is not a solvent above suspicion N,N-Dimethylformamide (DMF) is an aprotic polar solvent very popular in organic synthesis.…